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Methods using preference in pain research
Komárková, Lucia ; Vaculín, Šimon (advisor) ; Mrózková, Petra (referee)
The thesis deals with neuropathic pain measurement in laboratory mice and rats. Neuropathic pain is characterized besides evoked allodynia and hyperalgesia also by spontaneous pain and anhedonia, further motivational-affective part of pain is highlighted. Traditional pain threshold testing is not appropriate method to measure these aspects of pain. Therefore, the aim of the thesis is to describe preference methods in pain research. We focused on three methods - conditioned place preference, sucrose preference test and thermal place preference. The first mentioned method creates an association between pain relief and a specific place, which afterwards the animal prefers. The conditioned place preference can be used to detect spontaneous pain. Sucrose preference test monitors decrease in consumption of sugar water after exposure to chronic pain, which can be interpreted as a sign of depression, so thanks to this method we have the opportunity to explore the interaction between pain and depression. The thermal place preference method studies changes of preferences between the cold and hot plate after induction of pain or analgesics. The findings based on preference methods help us to examine all aspects of neuropathic pain and develop more options for pain treatment.
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Methods using preference in pain research
Komárková, Lucia ; Vaculín, Šimon (advisor) ; Mrózková, Petra (referee)
The thesis deals with neuropathic pain measurement in laboratory mice and rats. Neuropathic pain is characterized besides evoked allodynia and hyperalgesia also by spontaneous pain and anhedonia, further motivational-affective part of pain is highlighted. Traditional pain threshold testing is not appropriate method to measure these aspects of pain. Therefore, the aim of the thesis is to describe preference methods in pain research. We focused on three methods - conditioned place preference, sucrose preference test and thermal place preference. The first mentioned method creates an association between pain relief and a specific place, which afterwards the animal prefers. The conditioned place preference can be used to detect spontaneous pain. Sucrose preference test monitors decrease in consumption of sugar water after exposure to chronic pain, which can be interpreted as a sign of depression, so thanks to this method we have the opportunity to explore the interaction between pain and depression. The thermal place preference method studies changes of preferences between the cold and hot plate after induction of pain or analgesics. The findings based on preference methods help us to examine all aspects of neuropathic pain and develop more options for pain treatment.
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The Effect of Kinesiotaping on Pain Threshold Alteration of Lower Limbs and Pelvis in Latin American Sport Dance Couples
Černocká, Michaela ; Prokešová, Michaela (advisor) ; Vláčilová, Ivana (referee)
Title: The Effect of Kinesiotaping on Pain Threshold Alteration of Lower Limbs and Pelvis in Latin American Sport Dance Couples Objectives: The aim of this study is to monitor the alteration of the pain threshold in predilective points of lower limbs and pelvis during loaded regime and to compare these changes with the control group with no kinesio tape. Methods: This experimental study employs intervention of kinesio tape applied to inhibit m. gastrocnemius medialis et lateralis and for mechanical correction of hallux valgus. There were five couples in experimental group and five couples in control group. The pain threshold change was objectivised by pressure algometer. Results: The measured data showed that the kinesiotaping has a positive influence on pain threshold in sport dance couples. In most dancers (9 out of 10) kinesio tape contributed to increasing or smaller decreasing of pain threshold with respect to the other lower limb. In comparison with the control group, pain threshold of dancers in the experimental group increased or decreased less even despite acute or subacute injury of the taped lower limb. One more finding is that the postural function has an influence on the pain threshold change after load. Pain threshold had a downward tendency in investigated persons with a worse...
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Methods for measuring pain in animals
Štěrbová, Petra ; Vaculín, Šimon (advisor) ; Nerandžič, Vladimír (referee)
Pain in animals was almost completely overlooked in the last years. It was assumed that animals do not suffer because they are not able to tell it anyway. In a recent time we know that it's not truth and the animals can physically feel pain as we do. This thesis is summarization of the basic knowledge about the pain measurement of animals. However, there are two different approaches to the measurement of pain. The first one is based on the threshold of pain, the another one observes changes in behavior. There have been number of animal models developed in order to pain detection. Exploration of the pain in animals can help us to clarify mechanisms and treatments for serious and chronic neuropathic pain. From an ethical point of view, it's almost impossible to expose a person to serious neuropathic injury for experimental purposes. Therefore, in these cases, the animals are commonly used. And besides this fact, nowadays animals represent a full member of the family for many people, so it is something like moral obligation for us to relieve a pain in animals.
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Pain perception in elders
Vítková, Jana ; Vaculín, Šimon (advisor) ; Telenský, Petr (referee)
The aging of the population is one of the problems of the current period. With increasing age, we have to deal with the accompanying phenomenon more and more - the pain which significantly inconveniences the life and makes normal integration of elderly people into society impossible. This bachelor thesis summarises the present knowledge of pain in elderly people. It addresses the mechanism of pain perception, physiology of aging and types of pain which occur in elderly people. Some types of pain are accompanying diseases which occur during old age - neuropathic, chronic and oncologic pains. The higher occurrence of these types of pain could be explained by the progressive degeneration of nerve system during aging, either due to demyelization and reduction of the number of nerve fibres or due to accumulation of free radicals in the organism. On the other hand, there are some types of pain which elderly people feel with lower intensity - visceral and postoperative pain. At the same time, the pain threshold is increasing in the elderly people. This paradox, i.e. on one hand higher occurrence of chronic pain at higher intensity and on the other hand reduction of visceral pain and postoperative pain could be explained by diffuse noxious inhibitory controls. The current knowledge of the pain in the elderly is...
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